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姓名：薛晓畅 |
职称/职务：教授 |
电话： |
传真： |
电子信箱：xuexch@snnu.edu.cn |
研究方向：肿瘤和自身免疫性疾病的机制研究 |
办公地点：格物楼2304 |
一、个人简介
1998年于bet356亚洲版体育官网获学士学位，2005年于第四军医大学获生物化学与分子生物学专业博士学位。2008年晋升副教授，2011年遴选为硕士生导师，2019年在bet356亚洲版体育官网任教授。2009-2011年在美国阿拉巴马大学（UAB）和德州大学医学分部（UTMB）做博士后研究。主持国家“十二五”863重大项目子课题、国家自然科学基金、新药创制科技重大专项等7项。发表SCI论文60余篇；副主编、参编专著6部；授权国家发明专利9项。
二、主要研究领域及兴趣
1.肿瘤和自身免疫性疾病的机制研究；
2.基因工程蛋白质和多肽药物的开发研究。
三、承担的科研项目
1.国家自然科学基金青年项目：细胞核内Galectin-1与Foxp3相互作用的验证及生物学活性的初步探讨(31000406)，第一，2011.01-2013.12
2.国家自然科学基金面上项目：NF-κB和miR-103调节环路在类风湿性关节炎中的作用及机制研究(81373201)，第一，2014.01-2017.12
3.863子课题：肿瘤及自身免疫性疾病等治疗性疫苗关键技术及产品研发(2012AA02A407)，第一，2012.01-2015.12
4.陕西省重点研发计划项目：人肿瘤坏死因子重组疫苗rTNF-PADRE的研制(2017SF-178)，第一，2017.01-2018.12
5.新药创制科技重大专项《重组肿瘤血管靶向性改构人TNFα的研制》(2009ZX09103-672)，副组长(第二)，2009.01-2010.12
6.新药创制科技重大专项(2013ZX09J13102-01C)，副组长，2013.01-2015.12
7.新药创制科技重大专项(2011ZXJ09104-01B)，副组长，2011.01-2015.12
四、出版的著作
1.《The Research and Biology of Cancer I, Chapter 8: Novel rmhTNF-α: a Higher Anti-tumor Activity and a Lower Toxicity》, 2013, iConcept Press Ltd.,参编
2.《医学发展考》，2013，第四军医大学出版社，参编
3.《军事药学》，2013，第四军医大学出版社，参编
4.《医学精品讲座(第一辑)》，2008，第四军医大学出版社，参编
5.《蛋白质研究技术》，2007，第四军医大学出版社，副主编
6.《肿瘤研究前沿（第5卷）》，2005，西安交通大学出版社，参编
五、代表性论文
1.Gu J#, Mu N#, Jia B#, Guo Q#, Pan L, Zhu M, Zhang W, Zhang K, Li W, Li M, Wei L, Xue X*, Zhang Y*, Zhang W*. Targeting radiation-tolerant persister cells as a strategy for inhibiting radioresistance and recurrence in glioblastoma. Neuro Oncol. 2021: noab288. (#co-first author; *co-corresponding author)
2.Han B, Sun H, Yang X, Wang T, He C, Zhao K, An S, Guo C, Niu D, Xue X*, Kang J*. Ultrasound-assisted enzymatic extraction of Corni Fructus alpha- glucosidase inhibitors improves insulin resistance in HepG2 cells. Food Funct. 2021; 12(20): 9808-19.
3.An SJ, Niu D, Wang T, Han BK, He CF, Yang XL, Sun HQ, Zhao K, Kang JF*, Xue XC*. Total saponins isolated from Corni Fructus via ultrasonic- microwave assisted extraction attenuates diabetes in mice. Foods. 2021; 10(3): 670.
4.Han B, Niu D, Wang T, An S, Wang Y, Chen X, Bi H, Xue X*, Kang J*. Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice. Food Funct. 2020; 11(12): 10709-23.
5.Mu N#, Gu JT#, Huang TL#, Liu NN, Chen H, Bu X, Zheng ZH, Jia B, Liu J, Wang BL, Wang YM, Zhu ZF, Zhang Y, Zhang YQ, Xue XC*, Li M*, Zhang W*. Blocking discoidin domain receptor 2 (DDR2) reduces inflammation and joint destruction in rheumatoid arthritis by altering IL-15 and DKK1 signalling in fibroblast-like synoviocytes. Arthritis Rheumatol. 2020; 72(6): 943-56.
6.Gu J#, Liu J#, Huang T#, Zhang W, Jia B, Mu N, Zhang K, Hao Q, Li W, Liu W, Zhang W, Zhang Y, Xue X*, Zhang C*, Li M*. The protective and anti-inflammatory effects of a modified glucagon-like peptide-2 dimer in inflammatory bowel disease. Biochemical Pharmacology. 2018; 155: 425-33.
7.Jintao Gu#, Shuo Liu#, Nan Mu#, Tonglie Huang#, Wangqian Zhang, Huadong Zhao, Zhen Shu, Cun Zhang, Qiang Hao, Weina Li, Xiaochang Xue*, Wei Zhang*, Yingqi Zhang*. A DPP-IV-resistant glucagon-like peptide-2 dimer with enhanced activity against radiation- induced intestinal injury. J Control Release. 2017; 260: 32-45.
8.Mu N#, Gu J#, Huang T#, Zhang C, Shu Z, Li M, Hao Q, Li W, Zhang W, Zhao J, Zhang Y, Huang L, Wang S, Jin X, Xue X*, Zhang W*, Zhang Y*. A novel NF-κB/YY1/ microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis. Sci Rep. 2016; 6: 20059.
9.Xue X, Cao AT, Cao X, Yao S, Carlson ED, Soong L, Liu CG, Liu X, Liu Z, Duck LW, Elson CO, Cong Y*. Downregulation of MicroRNA-107 in intestinal CD11c+ myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression. Eur J Immunol. 2014; 44(3): 673-82.
10. Wei F#, Liu Y#, Guo Y, Xiang A, Wang G, Xue X*, Lu Z*. miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer. Mol Cancer 2013; 12(1): 81-93.
11. Xue X, Feng T, Yao S, Wolf KJ, Liu CG, Liu X, Elson CO, Cong Y. Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40. J Immunol, 2011; 187 (11): 5879-86.
12. Wang Y, Sun M, Chang F, Wang J, Wang Y*, Tang J, Zhang K, Gao L, Xue X, Wan Y*. The essential differences in microbial and chemical components of musk of different qualities secreted by captive male forest musk deer (Moschus berezovskii). Microb Biotechnol. 2022.
13. Su T#, Liu P#, Ti X#, Wu S, Xue X, Wang Z, Dioum E, Zhang Q.ΗΙF1α, EGR1 and SP1 Co-Regulate the Erythropoietin Receptor Expression Under Hypoxia: An Essential Role in the Growth of Non-Small Cell Lung Cancer Cells. Cell Commun Signal. 2019; 17 (1): 152.
14. Nan Mu#, Jintao Gu#, Nannan Liu#, Xiaochang Xue, Zhen Shu, Kuo Zhang, Tonglie Huang, Chu Chu, Wangqian Zhang, Li Gong, Huadong Zhao, Bo Jia, Dakuan Gao, Lei Shang*, Wei Zhang*, Qingdong Guo*. PRL-3 is a potential glioblastoma prognostic marker and promotes glioblastoma progression by enhancing MMP7 through the ERK and JNK pathways. Theranostics. 2018; (6): 1527-39.
15. Gao Y#, Li X#, Shu Z#, Zhang K, Xue X, Li W, Hao Q, Wang Z, Zhang W, Wang S, Zeng C, Fan D, Zhang W, Zhang Y, Zhao H*, Li M*, Zhang C*. Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer. Cell Death Dis. 2018; 9(4): 416-29.
16. Gao Y#, Wang Z#, Hao Q#, Li W, Xu Y, Zhang J, Zhang W, Wang S, Liu S, Li M, Xue X, Zhang W*, Zhang C*, Zhang Y*. Loss of ERαinduces amoeboid-like migration of breast cancer cells by down-regulating vinculin. Nat Commun. 2017; 8: 14483.
17. Liu H, Chen F, Wu W, Cao AT, Xue X, Yao S, Evans-Marin HL, Li YQ, Cong Y. TLR5 mediates CD172α(+) intestinal lamina propria dendritic cell induction of Th17 cells. Sci Rep. 2016; 6: 22040.
18. Wu W#, He C#, Liu C, Cao AT, Xue X, Evans-Marin HL, Sun M, Fang L, Yao S, Pinchuk IV, Powell DW, Liu Z*, Cong Y*. miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut. 2015; 64(11): 1755-64.
19. Zhao W#, Zhang C#, Shi M#, Zhang J#, Li M, Xue X, Zhang Z, Shu Z, Zhu J, Mu N, Li W, Hao Q, Wang Z, Gong L, Zhang W*, Zhang Y*. The DDR2-Annexin A2-MMP13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. Arthritis Rheumatol. 2014; 66(9): 2355-67.
20. Li W#, Wang L#, Jiang C#, Li H, Zhang K, Xu Y, Hao Q, Li M, Xue X, Qin X, Zhang C, Wang H, Zhang W, Zhang Y. UXT is a novel regulatory factor of regulatory T cells associated with Foxp3. Eur J Immunol. 2014; 44(2): 533-44.
六、授权专利
1.薛晓畅、刘烁、王增禄、张伟、张英起。人胰高血糖素样肽-2二串体蛋白及其制备方法。授权公告日：2015年11月25日，专利号：ZL201310002909.6，专利申请国：中国。
2.汪静、杨卫东、马温惠、邵亚辉、王喆、康飞、马晓伟、张英起、薛晓畅。NGR-VEGI融合蛋白及其编码基因与表达纯化方法。授权公告日：2015年6月3日，专利号：CN103160531A，专利申请国：中国。
3.张英起、薛晓畅、颜真、赵宁。破伤风毒素T细胞表位多肽与人B淋巴细胞刺激因子融合蛋白及其制备。授权公告日：2007年11月21日，专利号：ZL200510096372.X，专利申请国：中国。
4.张英起、唐量、韩苇、李萌、薛晓畅、孟洁如、包春杰、郝强、李维娜、 王增禄。一种Myostatin特异性抗体的治疗性疫苗及其制备方法。授权公告日：2010年2月3日，专利号：ZL200610104728.4，专利申请国：中国。
5.张英起、万一、薛晓畅、王增禄、赵宁。一种针对人TNF-α分子的自体疫苗的构建方法。授权公告日：2013年5月1日，专利号：ZL 201110303946. 1，专利申请国：中国。
